Cancer-Derived Extracellular Vesicles: Their Role in Sarcoma
Abstract
Soft tissue sarcomas (STS) are rare malignancies with limited responses to anticancer therapy. Extracellular vesicles (EVs) are a heterogeneous group of bi-lipid layer sacs secreted by cells into extracellular space. Investigations of tumor-derived EVs have revealed their functional capabilities, including cell-to-cell communication and their impact on tumorigenesis, progression, and metastasis; however information on the roles of EVs in sarcoma is currently limited. In this review we investigate the role of various EV cargos in sarcoma and the mechanisms by which those cargos can affect the recipient cell phenotype and the aggressivity of the tumor itself. The study of EVs in sarcoma may help establish novel therapeutic approaches that target specific sarcoma subtypes or biologies, thereby improving sarcoma therapeutics in the future.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Mar 26, 2022
- Source ID
- 10.3390/life12040481
Entities
People
- Anita Adib
- Lucia Casadei
- Raphael E Pollock
- Ruhi Sahu
- Shivangi Mohta
Organizations
- National Institutes of Health
- United States Department of Defense