Plasma 25-Hydroxyvitamin D Concentrations are Associated with Polyunsaturated Fatty Acid Metabolites in Young Children: Results from the Vitamin D Antenatal Asthma Reduction Trial
Abstract
Vitamin D deficiency contributes to a multitude of health conditions, but its biological mechanisms are not adequately understood. Untargeted metabolomics offers the opportunity to comprehensively examine the metabolic profile associated with variations in vitamin D concentrations. The objective of the current analysis was to identify metabolites and metabolic pathways associated with plasma 25-hydroxyvitamin D [25(OH)D] concentrations. The current study included children of pregnant women in the Vitamin D Antenatal Asthma Reduction Trial, who had 25(OH)D and global metabolomics data at age 1 and 3 years. We assessed the cross-sectional associations between individual metabolites and 25(OH)D using linear regression adjusting for confounding factors. Twelve metabolites were significantly associated with plasma 25(OH)D concentrations at both age 1 and 3 after correction for multiple comparisons, including three members of the n-6 polyunsaturated fatty acid (PUFA) metabolism pathway (linoleate, arachidonate, and docosapentaenoate) inversely associated with 25(OH)D. These PUFAs along with four other significant metabolites were replicated in the independent Childhood Asthma Management Program (CAMP) cohort. Both vitamin D and n-6 PUFAs are involved in inflammatory processes, and evidence from cell and animal studies demonstrate a plausible biological mechanism where the active form of 25(OH)D may influence n-6 PUFA metabolism. These relationships warrant further investigation in other populations.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 14, 2020
- Source ID
- 10.3390/metabo10040151
Entities
People
- Augusto A Litonjua
- Bo L Chawes
- Hans Bisgaard
- Jessica Lasky-Su
- Kathleen Lee-Sarwar
- Mengna Huang
- Priyadarshini Kachroo
- Rachel S Kelly
- Scott T Weiss
- Su Chu
Organizations
- National Heart, Lung, and Blood Institute
- National Human Genome Research Institute
- National Institute of Arthritis and Musculoskeletal and Skin Diseases
- Office of the Director
- United States Department of Defense