Ultra Sensitivity Silicon-Based Photonic Crystal Microcavity Biosensors for Plasma Protein Detection in Patients with Pancreatic Cancer
Abstract
Defect-engineered photonic crystal (PC) microcavities were fabricated by UV photolithography and their corresponding sensitivities to biomarkers in patient plasma samples were compared for different resonant microcavity characteristics of quality factor Q and biomarker fill fraction. Three different biomarkers in plasma from pancreatic cancer patients were experimentally detected by conventional L13 defect-engineered microcavities without nanoholes and higher sensitivity L13 PC microcavities with nanoholes. 8.8 femto-molar (0.334 pg/mL) concentration of pancreatic cancer biomarker in patient plasma samples was experimentally detected which are 50 times dilution than ELISA in a PC microcavity with high quality factor and high analyte fill fraction.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Mar 09, 2020
- Source ID
- 10.3390/mi11030282
Entities
People
- Chun-ju Yang
- Hai Yan
- Hamed Dalir
- Naimei Tang
- Ray T Chen
- Xiaochuan Xu
- Yas Al-hadeethi
- Yi Zou
Organizations
- Air Force Office of Scientific Research
- National Cancer Institute