DNA Microsystems for Biodiagnosis
Abstract
Researchers are continuously making progress towards diagnosis and treatment of numerous diseases. However, there are still major issues that are presenting many challenges for current medical diagnosis. On the other hand, DNA nanotechnology has evolved significantly over the last three decades and is highly interdisciplinary. With many potential technologies derived from the field, it is natural to begin exploring and incorporating its knowledge to develop DNA microsystems for biodiagnosis in order to help address current obstacles, such as disease detection and drug resistance. Here, current challenges in disease detection are presented along with standard methods for diagnosis. Then, a brief overview of DNA nanotechnology is introduced along with its main attractive features for constructing biodiagnostic microsystems. Lastly, suggested DNA-based microsystems are discussed through proof-of-concept demonstrations with improvement strategies for standard diagnostic approaches.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 23, 2020
- Source ID
- 10.3390/mi11040445
Entities
People
- Alana Torres Vidal
- Hieu Bui
- Igor L. Medintz
Organizations
- Defense Threat Reduction Agency
- Office of Naval Research
- United States Naval Research Laboratory