Protocol for Construction of Rat Nerve Stimulation Cuff Electrodes
Abstract
Peripheral nerve stimulation has emerged as a platform therapy to treat a wide range of disorders. Continued development and translation of these strategies requires that researchers have access to reliable, customizable electrodes for nerve stimulation. Here, we detail procedures to build three different configurations of cuff electrodes with varying numbers and orientations of contacts for nerve stimulation in rats. These designs are built with simple, widely available materials, using platinum–iridium electrodes assembled into polyurethane tubing. Moreover, the designs can easily be customized to increase versatility and individualize for specific stimulation applications. This protocol provides a resource to facilitate the construction and customization of stimulation cuffs to support preclinical nerve stimulation research.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 15, 2019
- Source ID
- 10.3390/mps2010019
Entities
People
- Crystal T. Engineer
- Jesse E Bucksot
- Kimiya Rahebi
- Manolo Rios
- Michael P Kilgard
- Seth A Hays
Organizations
- Defense Advanced Research Projects Agency
- Foundation for the National Institutes of Health