T Cell Response to SARS-CoV-2 Coinfection and Comorbidities
Abstract
For the past three years, COVID-19 has become an increasing global health issue. Adaptive immune cells, especially T cells, have been extensively investigated in regard to SARS-CoV-2 infection. However, human health and T cell responses are also impacted by many other pathogens and chronic diseases. We have summarized T cell performance during SARS-CoV-2 coinfection with other viruses, bacteria, and parasites. Furthermore, we distinguished if those altered T cell statuses under coinfection would affect their clinical outcomes, such as symptom severity and hospitalization demand. T cell alteration in diabetes, asthma, and hypertension patients with SARS-CoV-2 infection was also investigated in our study. We have summarized whether changes in T cell response influence the clinical outcome during comorbidities.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 15, 2023
- Source ID
- 10.3390/pathogens12020321
Entities
People
- Anil Kumar
- Aspen Pham
- Darby J. Ballard
- Eber Villazana
- Hao‐Yun Peng
- Jianxun Song
- Jugal Kishore Das
- Liqing Wang
- Xiaofang Xiong
Organizations
- National Institutes of Health
- Texas A&M University
- United States Department of Defense