Broadband Electrical Sensing of a Live Biological Cell with In Situ Single-Connection Calibration
Abstract
Single-connection in situ calibration using biocompatible solutions is demonstrated in single-cell sensing from 0.5 to 9 GHz. The sensing is based on quickly trapping and releasing a live cell by dielectrophoresis on a coplanar transmission line with a little protrusion in one of its ground electrodes. The same transmission line is used as the calibration standard when covered by various solutions of known permittivities. The results show that the calibration technique may be precise enough to differentiate cells of different nucleus sizes, despite the measured difference being less than 0.01 dB in the deembedded scattering parameters. With better accuracy and throughput, the calibration technique may allow broadband electrical sensing of live cells in a high-throughput cytometer.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 09, 2020
- Source ID
- 10.3390/s20143844
Entities
People
- Caroline Ladegard
- James C. M. Hwang
- Lei Li
- Xiao Ma
- Xiaotian Du
- Xuanhong Cheng
Organizations
- Air Force Office of Scientific Research
- Division of Electrical, Communications & Cyber Systems
- United States Army Research Laboratory