Identification of Podocyte Cargo Proteins by Proteomic Analysis of Clathrin-Coated Vesicles
Abstract
Clathrin-mediated endocytosis (CME) plays a fundamental role in podocyte health. Genetic ablation of genes implicated in CME has been shown to cause severe proteinuria and foot process effacement in mice. However, little is known about the cargo of clathrin-coated vesicles (CCVs) in podocytes. The goal of this study was to isolate CCVs from podocytes and identify their cargo by proteomic analysis.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jun 01, 2020
- Source ID
- 10.34067/kid.0000212020
Entities
People
- Christopher E. Pedigo
- Elizabeth Cross
- Eunice Baik
- Karen Ebenezer
- Kazunori Inoue
- Mario Schiffer
- Marwin Groener
- Shuta Ishibe
- Xuefei Tian
- Ying Wang
Organizations
- Friedrich-Alexander-Universität Erlangen-Nürnberg
- German Academic Exchange Service
- National Institutes of Health
- United States Department of Defense
- University Hospital Erlangen
- Yale School of Medicine
- Yale University