Integrin Signaling in Mammary Epithelial Cells and Breast Cancer
Abstract
Cells sense and respond to the extracellular matrix (ECM) by way of integrin receptors, which facilitate cell adhesion and intracellular signaling. Advances in understanding the mammary epithelial cell hierarchy are converging with new developments that reveal how integrins regulate the normal mammary gland. But in breast cancer, integrin signaling contributes to the development and progression of tumors. This paper highlights recent studies which examine the role of integrin signaling in mammary epithelial cells and their malignant counterparts.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Mar 01, 2012
- Source ID
- 10.5402/2012/493283
Entities
People
- Arthur W. Lambert
- Sait Ozturk
- Sam Thiagalingam
Organizations
- Boston University
- United States Department of Defense