Cochlear progenitor number is controlled through mesenchymal FGF receptor signaling
Abstract
The sensory and supporting cells (SCs) of the organ of Corti are derived from a limited number of progenitors. The mechanisms that regulate the number of sensory progenitors are not known. Here, we show that Fibroblast Growth Factors (FGF) 9 and 20, which are expressed in the non-sensory (Fgf9) and sensory (Fgf20) epithelium during otic development, regulate the number of cochlear progenitors. We further demonstrate that Fgf receptor (Fgfr) 1 signaling within the developing sensory epithelium is required for the differentiation of outer hair cells and SCs, while mesenchymal FGFRs regulate the size of the sensory progenitor population and the overall cochlear length. In addition, ectopic FGFR activation in mesenchyme was sufficient to increase sensory progenitor proliferation and cochlear length. These data define a feedback mechanism, originating from epithelial FGF ligands and mediated through periotic mesenchyme that controls the number of sensory progenitors and the length of the cochlea.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 27, 2015
- Source ID
- 10.7554/elife.05921
Entities
People
- David M. Ornitz
- Mark E Warchol
- Sung-Ho Huh
Organizations
- Hearing Health Foundation
- March of Dimes
- National Institutes of Health
- Office of Naval Research
- Royal National Institute for Deaf People
- Washington University in St. Louis