Hippocampome.org: a knowledge base of neuron types in the rodent hippocampus
Abstract
Hippocampome.org is a comprehensive knowledge base of neuron types in the rodent hippocampal formation (dentate gyrus, CA3, CA2, CA1, subiculum, and entorhinal cortex). Although the hippocampal literature is remarkably information-rich, neuron properties are often reported with incompletely defined and notoriously inconsistent terminology, creating a formidable challenge for data integration. Our extensive literature mining and data reconciliation identified 122 neuron types based on neurotransmitter, axonal and dendritic patterns, synaptic specificity, electrophysiology, and molecular biomarkers. All ∼3700 annotated properties are individually supported by specific evidence (∼14,000 pieces) in peer-reviewed publications. Systematic analysis of this unprecedented amount of machine-readable information reveals novel correlations among neuron types and properties, the potential connectivity of the full hippocampal circuitry, and outstanding knowledge gaps. User-friendly browsing and online querying of Hippocampome.org may aid design and interpretation of both experiments and simulations. This powerful, simple, and extensible neuron classification endeavor is unique in its detail, utility, and completeness.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 24, 2015
- Source ID
- 10.7554/elife.09960
Entities
People
- Alexander O. Komendantov
- Charise M. White
- Christopher L Rees
- David J Hamilton
- Diek W. Wheeler
- Giorgio A. Ascoli
Organizations
- Air Force Office of Scientific Research
- George Mason University
- National Institutes of Health
- National Science Foundation
- Northrop Grumman
- Office of Naval Research
- W. M. Keck Observatory