Stage-dependent differential influence of metabolic and structural networks on memory across Alzheimer’s disease continuum
Abstract
Large-scale neuronal network breakdown underlies memory impairment in Alzheimer’s disease (AD). However, the differential trajectories of the relationships between network organisation and memory across pathology and cognitive stages in AD remain elusive. We determined whether and how the influences of individual-level structural and metabolic covariance network integrity on memory varied with amyloid pathology across clinical stages without assuming a constant relationship.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 02, 2022
- Source ID
- 10.7554/elife.77745
Entities
People
- Fang Ji
- Juan Zhou
- Kok Pin Ng
- Kwun Kei Ng
- Nagaendran Kandiah
- Pedro Rosa-Neto
- Serge Gauthier
- The Alzheimer’s Disease Neuroimaging Initiative*
- Xing Qian
Organizations
- Duke–NUS Medical School
- McGill University
- Nanyang Technological University
- National Medical Research Council
- National Neuroscience Institute
- National University of Singapore
- Yong Loo Lin School of Medicine