Adaptive Immunomodulation-Based Therapeutics
Abstract
The Adaptive Immunomodulation-Based Therapeutics program will develop platform technologies that can interrogate and define the biological pathways leading to an immune response with the goal of developing and demonstrating new therapeutic interventions. One approach to achieve this capability will require the development of new tools to stimulate and measure responses of the nervous system in order to map the bioelectric code that controls the immune response as well as other critical organ functions. This program will also develop capabilities for serial measurements of metabolic state to identify correlates for health and early detection of disease. An additional approach involves characterizing the host response in patients with severe infections, and translating this response into a quantitative framework that can be used to guide modulation of the immune response. A further line of effort will pursue a detailed understanding of infectious diseases circulating in a community, with an aim to build capacity for the response to a crisis through managing current infectious disease challenges. The effort will employ sophisticated laboratory testing to evaluate the evolution of pathogens. Test beds in communities will be developed to evaluate the predictive algorithms by tracking infections in a community; influenza is an example of an infection that will be monitored. Advances made under the Adaptive Immunomodulation-Based Therapeutics program will improve our response capability against severe infectious diseases and biological threats and offer new avenues for treating disease with no available drugs, such as multiple drug resistant organisms. The ultimate goals for the Adaptive Immunomodulation-Based Therapeutics program are to enable an autonomous and continuous sense and response capability to regulate the human immune response and to develop decision support tools that help manage infectious diseases in a community. It is anticipated that these capabilities will ultimately provide enhanced protection against injury, enable life-saving rescue from hyper-immune activity, and stimulate advances in regenerative medicine.
Document Details
- Document Type
- Accomplishment
- Publication Date
- Oct 01, 2015
- Source ID
- 157cc5ea658a9a9e53a4facf7ebe10a0