Radiation Countermeasures (USUHS)
Abstract
Radiation Countermeasures (USU): For the Uniformed Services University of the Health Sciences (USU), this program supports applied research for advanced development of biomedical strategies to prevent and treat health consequences from exposure to ionizing radiation. It capitalizes on findings under PE 0602787HP, Medical Technology, and from industry and academia to advance novel medical countermeasures into and through pre-clinical studies toward newly licensed products. Program objectives focus on preventing or mitigating the health consequences from exposures to ionizing radiation alone or in combination with other injuries, in the context of probable threats to US forces in current tactical, humanitarian and counterterrorism mission environments. Findings from basic and developmental research are integrated into highly focused advanced technology development studies yielding protective and therapeutic strategies. FY 2019 Accomplishments: - Demonstrated an important finding that radiation injury (RI) and combined radiation injury (CI) significantly reduced nuclear respiratory factor 1 and 2 (NRF1/2) and mitochondrial complexes I-V, thereby leading to decreases in energy production in mouse brain. -Reported data on RI and CI decreased dynamin-related protein 1 (DRP1) and mitofusin 1 (Mfn1), resulting in mitochoondial remodeling in mouse brain. In addition, reported data showed RI and CI decreased AKT activation in mouse brain. - Reported data on combinational therapy of Ghrelin and Neulasta recovered energy production by recovering NRF1/2, mitochondrial complex III, shape integrity and pro-survival signal molecules in mouse brain.
Document Details
- Document Type
- Accomplishment
- Publication Date
- Oct 01, 2021
- Source ID
- 1a95e2349c1c097c71232adeeeb24fa9