16) Host Response
Abstract
Host Response assesses the human response of exposure to biological and chemical threat agents using operationally relevant exposure scenarios (acute versus chronic) and exposure routes (e.g., .inhalation, dermal, ingestion, etc.) and appropriate assessment methods and models. Data from host response studies are used to develop quantitative exposure limits (e.g. LD50 or ID50) and qualitative information (e.g. mechanism of action) to inform warfighter mission planning, requirements generation, capability development, model development, the larger CBDP Enterprise, Intelligence and other government stakeholders. The program, known as CRISTAL (Computational Rapid Identification and Scientific Threat Analysis) is modernizing to include predictive capabilities for rapidly assessing the human response to chemical and biological threat agents. In addition, host response will be working to close known knowledge gaps associated with traditional threats, including exploring synergistic effects associated with combinatorial agent exposures. Bioavailability of threats that are encapsulated to understand host response differences between exposures to encapsulated versus un-encapsulated threats will be also be assessed.
Document Details
- Document Type
- Accomplishment
- Publication Date
- Oct 01, 2024
- Source ID
- 1f7b9e09896109b4a5f62a0971f755ac