Mitigate the Global Impact of Sepsis Through ACESO (CARB) (Navy)

Abstract

This project seeks to demonstrate that the impact of sepsis (severe infections) in Egypt can be mitigated through the Austere Environment Consortium for Enhanced Sepsis Outcomes (ACESO) approach of discovering common, host-based pathogenic pathways for improved recognition and management of sepsis and point of care (POC) diagnostic and prognostic biomarker panels. Sepsis is the common path to end-organ damage and death for a large proportion of globally-important infectious diseases. This project will improve the understanding of disease pathogenesis and antimicrobial resistance mechanisms through network and biomarker analysis thus offering unique opportunities for improving sepsis diagnosis and management. Through systematic biology, it will develop insight into the disease pathogenesis of sepsis, and host factors which predict susceptibility, and sepsis severity provides opportunity for targeted interventions to forestall morbidity and mortality. Furthermore, enhanced knowledge of emerging antimicrobial resistance in strategic regions informs ongoing surveillance and mitigation efforts of critical importance to deployed forces. Successful completion of this project will provide reliable antimicrobial resistance data for forces deploying to Egypt and the region and also document improved methods for the treatment and management of sepsis. ACESO is an international consortium of sepsis researchers led by Naval Medical Research Center (NMRC) that has established a network of sepsis research sites in SE Asia and Sub-Saharan Africa to improve clinical outcomes and advance our understanding of pathogenesis, biomarkers of sepsis and antimicrobial resistance trends. The largest infectious disease hospital in Egypt, Abbassia Fever Hospital, provides critical severe infection and antimicrobial resistance data from the North African Theater. This project supports (both directly and indirectly) Global Health Security Agenda priorities: Combat Antibiotic Resistance Bacteria (CARB); Prevent Avoidable Epidemics; Detect Threats Early; and Respond Rapidly and Effectively to biological threats of international concern.

Document Details

• Document Type: Project
• Publication Date: Oct 01, 2021
• Source ID: 247B_0603115DHA_2_0130_PB_2021

Tags

Fields of Study

• Medicine

Readers

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