Aptamer Selection and Integration in Nanoparticle-Based Detection Systems
Abstract
This project discovered novel biological recognition elements, specifically DNA and/or RNA oligomers known as aptamers, that bind with high specificity and sensitivity to molecules of interest. Several different platforms were investigated at the Air Force Research Laboratory to convert this binding event into optical and electrical signals which allowed for implementation into a handheld sensor. The primary output of this project is to deliver a selection method for aptamers that can be used to detect multiple chemicals and detection assays for multiple analytes, which have been examined with several platforms, as well as a prototype microfluidic field effect transistor sensor. This will enable the development of a handheld forensic device capable of detecting trace levels of particular chemicals.
Document Details
- Document Type
- Accomplishment
- Publication Date
- Oct 01, 2013
- Source ID
- 27d6ef97c8f6c8e0dbb296a4eee89ff5