Adaptive Immunomodulation-Based Therapeutics
Abstract
The Adaptive Immunomodulation-Based Therapeutics program will develop platform technologies to interrogate and define the biological pathways that will enhance operational readiness for DoD personnel. This program will aid the warfighter by improving immune response, minimizing inflammation, and restoring critical organ function post trauma. One approach to achieve this capability will require the development of new tools to stimulate and measure responses of the nervous system in order to harness the bioelectric code, enabling targeted therapy without the need for pharmacological products, ultimately reducing logistical requirements. An additional approach involves characterizing the host response in patients with severe infections, which provides a quantitative framework to guide therapy. Algorithms will be developed to evaluate and predict various physiological conditions for military personnel. Advances made under the Adaptive Immunomodulation-Based Therapeutics program will improve the response capabilities against severe biological threats and offer new avenues for treating disease or organ function to improve force readiness.
Document Details
- Document Type
- Accomplishment
- Publication Date
- Oct 01, 2019
- Source ID
- 32c1a7bd029a0a4794822649974cbb68