Autonomous Diagnostics to Enable Prevention and Therapeutics (ADEPT)*
Abstract
*Previously funded in Synthetic Biology in PE 0601101E, Project TRS-01 The overarching goal of the Autonomous Diagnostics to Enable Prevention and Therapeutics (ADEPT) program is to increase our ability to rapidly respond to a disease or threat and improve individual readiness and total force health protection. Service members in deployed settings have limited access to health care. New methods and devices are needed to address critical conditions on-site, to allow improved care at field hospital, fleet, and air transport settings, and to enable rapid response to emerging threats. This applied research effort will focus on development of devices for integrated diagnostics across multiple echelons of care: 1) Simple to operate diagnostic devices for critical biomarkers at the point of need; 2) highly multiplexed diagnostic devices for broad spectrum diagnostic and response to emerging threats in an automated format; and, 3) the ability to rapidly develop, integrate and distribute new assays for detection of new biomarkers and emerging threats. Research thrusts include: optimization of methodologies for extraction of targeted biomarkers from a biospecimen that has been room-temperature stabilized in a dried format; demonstration of novel molecular detection approaches towards specific biomarkers; optimization of integrated simple-to-operate diagnostic devices (sample in, results out); demonstration of novel molecular approaches for multiplexed analysis over the same or different classes of biomarkers; and, integration of sample preparation and analysis methods. A companion basic research effort is budgeted in PE 0601117E, Project MED-01.
Document Details
- Document Type
- Accomplishment
- Publication Date
- Oct 01, 2012
- Source ID
- 46fbc13e7d148917a92123b51d642fde
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- Root: BIOMEDICAL TECHNOLOGY