BioDesign
Abstract
BioDesign will employ system engineering methods in combination with biotechnology and synthetic chemical technology to create novel beneficial attributes. BioDesign mitigates the unpredictability of natural evolutionary advancement primarily by advanced genetic engineering and molecular biology technologies to produce the intended biological effect. This thrust area includes designed molecular responses that increase resistance to cellular death signals and improved computational methods for prediction of function based solely on sequence and structure of proteins produced by synthetic biological systems. Development of technologies to genetically tag and/or lock synthesized molecules would provide methods for prevention of manipulation ("tamper proof" synthetic biological systems). This thrust will also develop new high-throughput technologies for monitoring the function of cellular machinery at the molecular level and the response(s) of that machinery to physical, chemical, or biological threats. While conventional approaches typically require decades of research, new high-throughput approaches will permit rapid assessment of the impact of known or unknown threats on identified biomolecules and cell function.
Document Details
- Document Type
- Accomplishment
- Publication Date
- Oct 01, 2015
- Source ID
- 53dc0ae6e29128b0041901027947a8e5