Systems Biology
Abstract
The core capability for multidisciplinary applied research in systems biology enables integration and analysis of complex data from human and animal studies and development of computational network models, allowing researchers to differentiate among molecular signatures (unique combinations of biological molecules corresponding to clinical conditions) of disease, and supports transition of research to clinical applications. Conduct applied research to identify and characterize (the substance itself and how it causes harm) toxic substances, e.g. toxic industrial chemicals. The molecular and physiological markers of intoxication are then applied to support diagnostic tools development of medical countermeasures. Current studies are addressing exposures to industrial chemicals, toxicogenomics (study of what genes are involved with responding to a toxic substance and those genes associated with susceptibility to the toxic substance) of metals, health surveillance with assessment of micro-biome, metabolomics of heat injury, and modeling toxicity pathways. The task funding for the toxic substances research effort moves to project 869 in FY17.
Document Details
- Document Type
- Accomplishment
- Publication Date
- Oct 01, 2017
- Source ID
- 57109add6ef5d74ea6a11822ba03640a
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- Root: Medical Technology