Autonomous Diagnostics to Enable Prevention and Therapeutics (ADEPT)
Abstract
The Autonomous Diagnostics to Enable Prevention and Therapeutics (ADEPT) program will develop the underlying technologies to rapidly respond to a disease or threat and improve individual readiness and total force health protection by providing capabilities which are currently available only in centralized laboratories in the U.S. to non-tertiary care and individual settings. ADEPT will develop and exploit biological tools for the in vivo creation of nucleic acid circuits that continuously and autonomously sense and respond to changes in physiologic state and for novel methods to target delivery, enhance immunogenicity, or control activity of vaccines, potentially eliminating the time to manufacture a vaccine ex vivo. ADEPT advancements to control cellular machinery include research to optimize orthogonality and modularity of genetic control elements; identify methods to increase sensitivity and specificity; and demonstrate methods to control cellular machinery in response to changes in physiological status. ADEPT will develop methodologies for measuring health-specific biomarkers from a collected biospecimen to enable diagnostics at the point-of-need or resource limited clinical facilities (point-of-care), in-garrison or deployed. Additionally, ADEPT will develop techniques that will enable the rapid establishment of transient immunity through stimulation of the production of components of the immune system to impart effective but temporary protection. This transient immunity would bridge the time gap between the delivery of a vaccine and the development of a long term protective immune response. Applied research efforts are budgeted in PE 0602115E, Project BT-01.
Document Details
- Document Type
- Accomplishment
- Publication Date
- Oct 01, 2019
- Source ID
- 79e6beb2925f136d797e194a75d9f871