Brain Injury and Disease Prevention, Treatment and Research
Abstract
Brain Injury and Disease Prevention, Treatment and Research is focused upon identifying drugs that will interfere with pathological tau prion formation in the brains of service members who are at risk for developing CTE and other neurodegenerative diseases following repeated TBI. Service members who have served in combat and have received repeated impact and/or blast TBIs are at risk for developing chronic traumatic encephalopathy (CTE) and other neurodegenerative diseases which are associated with significant persistent behavioral/neurologic manifestations. Currently, there are no validated means for diagnosing these problems in living patients or drugs to effectively treat them. The overall mission of this program is to develop drug candidates that will effectively block the formation of brain tau prions that can be entered into clinical trials for the prevention and/or treatment of CTE and other neurodegenerative disorders in at-risk active duty and retired service members.
Document Details
- Document Type
- Accomplishment
- Publication Date
- Oct 01, 2021
- Source ID
- 888c02e3a8cb7eb35139a7cd5eb1c964