Radiation Countermeasures (USUHS)
Abstract
Radiation Countermeasures (USU): For the Uniformed Services University of the Health Sciences (USU), this program supports applied research for advanced development of biomedical strategies to prevent and treat health consequences from exposure to ionizing radiation. It capitalizes on findings under PE 0602787HP, Medical Technology, and from industry and academia to advance novel medical countermeasures into and through pre-clinical studies toward newly licensed products. Program objectives focus on preventing or mitigating the health consequences from exposures to ionizing radiation alone or in combination with other injuries, in the context of probable threats to US forces in current tactical, humanitarian and counterterrorism mission environments. Findings from basic and developmental research are integrated into highly focused advanced technology development studies yielding protective and therapeutic strategies. In addition to the primary achievement of research objectives, the program educates Federal employees as a benefit to the public they serve through Federal service, through support to civil authorities, and in non-Federal professional and academic collaborations. FY21 Accomplishments: (1)There are several radiation countermeasures (BIO 300, TPOm, gamma-tocotrienol, BBT-059, PLX-R18, CDX 301) under advance development and few of them may be FDA approved in near future. (2)Identified and evaluated the transcriptomic profiles of NHP brain compartments to profile the global transcriptomic changes in different brain compartments of NHPs exposed to radiation. (3)Performed the study of two new candidates EC-18 and YK-4-250. (4)Completed EC-18 study. (5)Completed 30 day survival efficacy for Myelo-001 and LA-GM-CFS (6)Performed safety study for YK-4-250 (7)Performed 30 day survival efficacy study of EC-18 and YK-4-250. (8)Tested new candidates for basic toxicity and preliminary survival efficacy at a dose of LD70/30 to LD90/30. (9)In 2019/2021, 44 manuscripts were published.
Document Details
- Document Type
- Accomplishment
- Publication Date
- Oct 01, 2023
- Source ID
- 9b943b706ef7404456867ec178ae13fb