Dialysis-Like Therapeutics
Abstract
Sepsis, a bacterial infection of the blood stream, is a significant cause of injury and death among combat-injured soldiers. The key goal of this program is to run the blood volume (approximately five liters) through an external machine (akin to a dialysis system) and literally scrub out harmful bacteria and their toxins. The proposed approach is low-shear/low-resistance fluidic structures to connect cellular and biomolecular purification techniques for blood purification. Initial basic research will develop novel low-shear, low-resistance fluidic structures that enable rapid, large volume blood filtration. Additional research will develop novel intrinsic separation techniques that selectively remove bacteria, toxins and host cells from complex fluids, as well as new methods for continuous sensing of these components. Finally, research into predictive control techniques for directing patient health will close the sense, scrub, and control loop. The applied research portion of the program is budgeted in PE 0602115E, Project BT-01.
Document Details
- Document Type
- Accomplishment
- Publication Date
- Oct 01, 2012
- Source ID
- 9e447f9b4b1c9734c570da8effe0254c