STUDIES ON THE PROTECTIVE ACTION OF SULFHYDRYL COMPOUNDS AGAINST X- IRRADIATION

Abstract

Cysteine, in a concentration of 850 mg/kg body weight administered intravenously 10 min prior to total body irradiation with 880 r, counteracted the inhibiting effect of x-rays on nucleic acid synthesis in the intestinal mucosa of the albino rat. Immediately after irradiation the rats received 20-50 micro-c P to the power of 32 intraperitoneally. The small intestine was used for determining the inorganic tissue P and desoxypentose nucleic acid P and their specific activities.

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Document Details

Document Type
Technical Report
Publication Date
Nov 12, 1952
Accession Number
AD0005468

Entities

People

  • A. Krebs
  • N. Puckett
  • R. Ransom
  • S. Spradling
  • W. Parr

Organizations

  • United States Army Medical Research Laboratory

Tags

DTIC Thesaurus Topics

  • Acids
  • Body Weight
  • Cysteine
  • Gamma Rays
  • Hydroxides
  • Inhibition
  • Intervals
  • Intestines
  • Ionizing Radiation
  • Metabolism
  • Nucleic Acids
  • Radiation
  • Shielding
  • Small Intestine
  • Sulfhydryl Compounds
  • Time Intervals
  • X Rays

Fields of Study

  • Chemistry
  • Physics

Readers

  • Molecular and Cellular Biochemistry
  • Nuclear and Radiation Engineering.
  • Toxicology/Environmental Toxicology

Technology Areas

  • Biotechnology