STUDIES ON THE PATHOGENESIS AND IMMUNITY OF TULAREMIA

Abstract

The purified polysaccharide (I) from Bacterium tularense was only slightly immunogenic to 100 LD50 doses of B. tularense in white mice and appeared to enhance the virulence of a partially virulent strain. The relation of Ascoli antigen to I is not understood; both I and the Ascoli antigen sensitized red cells and acted as antigens in precipitin tests and skin tests. The Ascoli antigen, I, and the I-sensitized red cells produced immunity in white rats. A study of killed culture vaccines indicated that smooth strains were more immunogenic than nonsmooth strains. Cells were killed more frequently by ether and Me2CO than by PhOH. Electro-phoresis studies indicated a component in the smooth virulent and avirulent strains which was lacking in the nonsmooth avirulent strains.

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Document Details

Document Type
Technical Report
Publication Date
Jul 08, 1953
Accession Number
AD0015528

Entities

People

  • Cora M. Downs

Organizations

  • University of Kansas

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Animals
  • Antibodies
  • Blood
  • Carbohydrates
  • Chemistry
  • Health Services
  • Hemagglutination Tests
  • Immune Serums
  • Immunity
  • Immunization
  • Infectious Diseases
  • Materials
  • Medical Personnel
  • Polysaccharides
  • Rodents
  • Skin Tests

Fields of Study

  • Biology

Readers

  • Immunology

Technology Areas

  • Biotechnology