THE INFLUENCE OF IONIZING RADIATION ON MITOSIS IN THE CORNEAL EPITHELIUM OF THE RAT. I. MORPHOLOGICAL CHANGES INDUCED BY X-IRRADIATION AND THE EFFECTIVENESS OF BAL AND CYSTEINE IN REDUCING THE FREQUENCY OF THESE CHANGES

Abstract

A 300-r irradiation of the corneal epithelium of the rat resulted in a steady decrease in mitoses. Sixty minutes after irradiation the cells which were dividing at the time of exposure were characterized by chromosome stickiness resulting in bridges at anaphase and telophase. A structural effect which was observed in the dividing cells 24 hr after irradiation was characterized by chromosome fragments and bridges in the anaphase and telophase. The effect was produced in young and adult rats exposed to local or total body irradiation and to hard or soft x-rays. Cysteine instilled in the eyes prior to irradiation reduced the frequency of the structural effect, but the instillation of 2,3-dimercaptopropanol did not significantly decrease the number of morphological changes produced.

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Document Details

Document Type
Technical Report
Publication Date
Jan 12, 1953
Accession Number
AD0020875

Entities

People

  • Robert G. Ransom

Organizations

  • United States Army Medical Research Laboratory

Tags

DTIC Thesaurus Topics

  • Acetic Acid
  • Biomedical Research
  • Cells
  • Chemical Warfare Agents
  • Chromosomes
  • Cysteine
  • Epithelium
  • Eye
  • Frequency
  • Genetics
  • Hard X Rays
  • Ionizing Radiation
  • Physiological Effects
  • Radiation
  • Soft X Rays
  • Tissues
  • X Rays

Readers

  • Molecular Biology and Genetics
  • Nuclear and Radiation Engineering.
  • Toxicology/Environmental Toxicology