TASK 3. ANALOGS OF TETRAHYDROCANNABINAL-POTENTIAL CW AGENTS

Abstract

One of the most active tetrahydrocannabinol analogs mentioned by Adams (Formula I, R=2-nonyl) has been completed. The preparation of the second of Adams' compounds R=1,2-dimethylheptyl) is now at the stage of 2(3,5dimethoxyphenyl)-3-methyloctene-2 and requires four more steps. The preparation of nitrogen and sulfur analogs is being approached by two different methods which were suggested in the previous report. One starting with 3,5-dinitrobenzoic acid has been carried through five steps to 5-methoxy-5-chlorobenzoic acid. The second method which involves the preparation of 3-amino-5-hydroy n-amyl benzene from the corresponding dihydroxy compound has been shown to be feasible. The preparation of 3,5-dibydroxy n-amyl benzene from 3,5-dimethoxyphenyl butyl ketone has presented unexpected difficulties.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 1953
Accession Number
AD0045973

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  • D. E. Winkler

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  • Chemistry

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