TASK 3. ANALOGS OF TETRAHYDROCANNABINOL-POTENTIAL CW AGENTS

Abstract

The preparation of Adams' most active tetrahydrocannabinol analog (Formula I, R = 1,2-dimethylheptyl) has been delayed at the next to the last step due to the low yield of the pyrone. Work on the preparation of a compound having an amino group in the alkyl side chain (Formula T, R = 2-aminoethyl) has been started. The preparation of analogs with nitrogen or sulfur in the five position via 3-amino-3-amyl phenol has been delayed awaiting the development of a satisfactory process for converting amyl-3,5-dihydroxybenzene to the desired amino compound. In the meantime, 1-hydroxy-3-n-amyl 9-methyl-7,8,9,10-tetrahydro-6-dibenzopyrone (Formula 11) has been prepared and efforts are being made to convert this pyrone to a nitrogen analog.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 1953
Accession Number
AD0046025

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  • D. E. Winkler

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  • Acetic Acid
  • Amides
  • Boiling
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  • Nitrogen
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  • Chemistry

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