POTENTIAL CW AGENTS. TASK 3. ANALOGS OF TETRAHYDROCANNABINOL

Abstract

The preparation of Adams' most active tetrehydrocannabinol analog (Formula I, R=1,2-dimethylheptyl), and of synthetic tetrahydrocannabinol (I, R=n-anyl) have been completed. Work on the preparation of an analog having an amino group in the alkyl side chain (I, R=2-aminoethyl) is at the stage of beta-(3,5-dimethoxyphenyl) ethylanine. The pyrons related to tetrahydrocannabinol (II, R=n-amyl) has been reaction with aqueous ammonia to produce a high melting material which may be a phenanthridone. A satisfactory method has been developed for the conversion of amyl-3,5-dihydroxybenzene to 3-amino-5-amylphenol. An attempt will be made to condense this aminophenol with pulegone to give a nitrogen analog of tetrahydrocannabinol. The synthesis of pulegone from isopulegol has been accomplished.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 1953
Accession Number
AD0046050

Entities

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  • D. E. Winkler

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  • C4I
  • Weapons Technologies

DTIC Thesaurus Topics

  • Alcohols
  • Classification
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  • Conversion
  • Critical Temperature
  • Desiccants
  • Glass Transition Temperature
  • Hydroxides
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  • Melting
  • Melting Point
  • Nitrogen
  • Nitrogen Compounds
  • Security
  • Transition Temperature

Fields of Study

  • Chemistry

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