Separation of Compounds Differing in Isotopic Composition.
Abstract
The patent application describes the separation of compounds differing in isotopic composition by introducing a mixture of compounds into a chromatographic column containing a lanthanide chelate as a stationary phase. A fraction which is at least enriched with one of the compounds of the mixture is eluted from the column. The process is particularly applicable to the separation of a deuterated isomer from an isotopic mixture of organic compounds containing an electron donor group. The invention is based upon the discovery that two or more of such compounds differing only in isotopic composition, i.e., deuterium atom or atoms substituted for hydrogen atom or atoms, exhibit significant differences in the degree of interaction with the lanthanide chelates.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 04, 1974
- Accession Number
- AD0164840
Entities
People
- Robert E. Sievers
Organizations
- United States Department of the Air Force