THE EFFECT OF PHYSICAL EXERCISE ON CHOLESTEROL-INDUCED ATHEROSCLEROSIS IN RABBITS
Abstract
Two groups of ten 3-month-old, male, New Zealand white rabbits were fed an atherogenic diet, ad libitum. This diet contained 0.5% cholesterol and 5% fat (by weight) during the first 63 days for Group I and the first 31 days for Group II; during the last 40 days the diet contained 0.25% cholesterol and 3.5% fat. Exercise, given up to 2 hours per day in a motor-driven drum, was started simultaneously with the diet for four of the animals of Group II; it was started for four of the animals in Group I after 34 days on theATHEROGENIC DIET. The effective exercise given was estimat d as being only about one-half that given the animals in the previous year's experiment. The ad libitum diet resulted in a much higher intake by the controls than by the exercised animals, with respect to cholesterol, fat and total number of calories. The controls gained an average of 500 to 700 g more than the experimental rabbits. The amount of exercise was considered inadequate in relation to the cholesterol and fat consumed; no significant difference was observed between the exercised and sedentary animal with regard to the blood cholesterol levels, appearance of the serum, grossly visible aortic atherosclerosis, or microscopic quantitative evaluation. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 1961
- Accession Number
- AD0255517
Entities
People
- Cato Ohrn Gudbrandsen
Organizations
- University of Washington