STUDIES ON METABOLISM AND MECHANISMS OF DESTRUCTION OF THE FORMED ELEMENTS OF THE BLOOD
Abstract
Dialyzable plasma phosphorous is not incorporated into erythrocyte lipids. Plasma phospholipids emulsified in aqueous media by ultrasonic vibration are incorporated into the erythrocyte lipids at the same rate that they are incorporated from whole plasma. Influx of lipid phosphorous from plasma is greatly increased over normal when erythrocytes stored in ACD solution at 4 C. for less than 4 wk are then incubated at 37 C. Erythrocytes from patients with Hereditary Spherocytosis show rapid alterations in the membrane lipids upon in vitro incubation. Plasma and er throcytes from patients with Acanthocytosis show marked reductions in their content of lecithin and linoleic acid. In vivo removal mechanisms, in addition to the metabolic defect, are essential in producing hemolytic anemia in subjects with glucose-6-PO4 dehydrogenase deficiency. Erythrocyte calcium may exist in an easily exchangeable pool (30%) and a slowly exchangeable pool (70%). Single intravenous administration of EDTA (200 mg/kg.) produces vacuolar changes of enal proximal tubule epithelium in the dog. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- May 31, 1961
- Accession Number
- AD0256734
Entities
People
- Lawrence E. Young
- Scott N. Swisher