ANTI-RADIATION DRUGS DERIVED FROM SULFINAMIDES AND N-SULFINYLAMINES

Abstract

The possible preparation of N-sulfinyl derivatives of 2-aminoethanethiol and p-aminobenzenethiol by reaction of bis-(aminoethyl)disulfide and bis-(4-aminophenyl)-disulfide with thionyl chloride under a variety of conditions has been studied. The reaction of N-(2-chloroethyl)-benzenesulfinamide and N-(3-chloropropyl)-benzenesulfinamide with reagents which usually convert halides to thiols gave no N-(mercaptoalkyl)-benzenesulfinamide. Various methods for the preparation of hydrazinothiols have been studied. A promising sequence is HSCH2CO2CH3 yields HSCH2CON(CH3)NH2 yields HSCH2CH2N(CH3)NH2. (Author)

Document Details

Document Type
Technical Report
Publication Date
Jun 01, 1961
Accession Number
AD0257020

Entities

People

  • Walter T. Jr. Smith

Organizations

  • University of Kentucky

Tags

DTIC Thesaurus Topics

  • Chemical Compounds
  • Chlorides
  • Chlorine Compounds
  • Halides
  • Radiation
  • Sequences

Fields of Study

  • Chemistry

Readers

  • Electrochemical Engineering/ Fuel Cell Technologies
  • Military Logistics and Supply Chain Management
  • Toxicology/Environmental Toxicology