METABOLIC DISORDERS AND THERAPEUTIC APPROACHES IN RENAL FAILURE
Abstract
Following supra lethal x-irradiation in dogs, the re-injection of autologous marrow removed before irradiation does not prolong the life of kidney homografts. Injection of homogenate of the contralateral kidney inhibits the increase in weight seen in the control animal's remaining kidney following nephrectomy. Cortisone treatment prolongs the survival of skin homografts in rabbits. In studies of fructose clearance in dogs a tubular maximum for fructose reabsorption was demonstrated. Pre-immunization of ambulatory adult volunteers with human leukocytes show acceleration of skin grafts subsequently placed from the donors. Sequential study has been made in man of the development of first set accelerated and white graft rejection patterns in skin homografts. Twelve arterio-venous bypass catheters have been placed for the facilitation of hemodialysis in acute and chronic uremia. In one patient such a shunt remained in place for 112 days and a second shunt for 71 days. In the other patients problems of clotting and infection necessitated removal before adequate therapy with dialysis could be obtained. In the patient whose shunts remained in for the periods of 112 and 71 days useful prolongation of life was obtained in spite of chronic terminal uremia. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 1961
- Accession Number
- AD0257301
Entities
People
- John P. Merrill