A STUDY OF THE SYNTHESIS OF 2-TRIFLUOROMETHYL PYRIMIDINES
Abstract
Phenylbutanedione-1,3 and 2,4-pentanedione were reacted with trifluoroacetamidine in the presence of sodium ethoxide. A crystalline product melting at 38.4 C was recovered from the reaction of 2,4-pentanedione and trifluoroacetamidine and tentatively identified by its IR spectra as 2-trifluoromethyl-4,6-diemthylpyrimidine. The reaction of trifluoroacetamidine and phenylbutanedione-1,3 in the presence of sodium ethoxide yielded a white crystalline product (melting at 90.3 C) which was also tentatively identified as the 2-trifluoromethyl4-methyl-6-phenylpyrimidine. The amidine of trifluoroacetic acid reacted in a manner described for the reaction of an amidine with a beta-diketone. Yields obtained (10-34%) were within the limits reported for many other pyrimidine syntheses, influenced in part by the instability of trifluoroacetamidine. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 1961
- Accession Number
- AD0258217
Entities
People
- John A. King
Organizations
- Naval Air Weapons Station China Lake