Erythropoietic Stimulating Factor Production in Pubescent Mice after a Single Exposure to Hypoxia.
Abstract
When animals are exposed continuously to hypoxia, the following sequence of hematological events occurs: production of erythropoietic stimulating factor (ESF), reticulocytosis, and polycythemia. Humoral changes occur during the first day atALTITUDE, BUT IT IS NOT KNOWN HOW SOON EST is produced or whether it is produced equally by juveniles and adults alike. In this experiment these factors are investigated: (a) ESF production after short-time hypoxic exposure and (b) ESF production under the same conditions in pubescent BDF1 mice. The results indicate that ESF is produced in this strain of mice after a six-hour exposure to 22,000 feet. It is further demonstrated that these mice have augmented response to hypoxia at the time of increased endocrine function at puberty. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 20, 1960
- Accession Number
- AD0258570
Entities
Organizations
- Naval Aerospace Medical Institute