INJECTION OF A VOLATILE SUBSTANCE, ETHER, INTO THE BLOODSTREAM, AND ITS ELIMINATION FROM THE LUNGS

Abstract

The elimination in the lungs of a volatile liquid (ether) injected into the blood stream has been measured by means of a whole body plethysmograph, using dogs. The mean circulation time from the pulmonary artery to the vessels of gas exchange was 1.1 seconds. This was 28% of the pulmonary circulation time from pulmonary artery to leftATRIUM. The volume of gas evolved into the alveoli corresponded to that calculated from the partition coefficient and lung density. Reabsorption into the blood occurred slowly while the breath was held. If hyperventilation has been used, most of the ether injected would have been blown off from the lungs without ever reaching the systemic circulation. The application of this principle to other gases should be of interest, and may be predicted from the information obtained using ether. (Author)

Document Details

Document Type
Technical Report
Publication Date
Jun 30, 1961
Accession Number
AD0259194

Entities

People

  • A.b. Du Bois
  • J. Soni
  • K.a. Feisal

Organizations

  • University of Pennsylvania

Tags

DTIC Thesaurus Topics

  • Anatomy
  • Arteries
  • Biological Sciences
  • Blood
  • Body Fluids
  • Coefficients
  • Elimination
  • Fluids And Secretions
  • Hemic And Immune Systems
  • Respiration Disorders
  • Respiratory Physiological Processes

Fields of Study

  • Medicine

Readers

  • Cardiovascular Physiology
  • Combustion and Flow Dynamics.