A STUDY OF OSTEOGENESIS AND THE HEALING OF FRACTURES USING ALKALINE PHOSPHATASE AND CHONDROITIN SULPHATE
Abstract
Areas of particular interest are indicated and further study to verify these hypotheses suggested. The more significant observations are summarzed. Gelfoam, Ivalon, anorganic bone, and boiled-defatted bone treated with chondroitin sulphate or alkaline phosphatase, and implanted intrmuscularly, failed to stimulate osteogenesis. Intramuscularly and within the femoral defect, the implant materials, both treated and control, were well accepted eliciting a slight to mild inflammatory response of short duration. The treated implants and the controls did not effect the pattern of healing over the bony defect. Three cellular zones were defined over the defect, an outer zone of fibrous tissue, a middle zone of cartilage, and an inner zone of proliferating host bone. In a femoral defect, boiled-defatted bone treated with chondroitin sulphate, showed a greater degree of invasion by host bone than the alkaline phosphatase treated implants or the control. The control was primarily encapsulated in fibrous tissue with very little bony invasion. Intramuscularly, and at the infrabony sites, gelfoam shows the most rapid rate of resorption, followed by Ivalon, boiled-defatted bone, and anorganic bone. Within a femoral defect, the heterogenous materials, both treated and control, do not stimulate osteogenesis, are not resorbed to any extent but are entrapped in host bone. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 28, 1961
- Accession Number
- AD0259301
Entities
People
- Howard Aduss