AORTIC ARTERIOSCLEROSIS IN THE DOG FOLLOWING LOCALIZED AORTIC IRRADIATION WITH ELECTRONS
Abstract
The inferior segments of the abdominal aortas of 15 dogs were irradiated with electrons in doses ranging from 1000 to 9500 rads, and were examined histologically at intervals ranging from 2 weeks to 17 months following irradiation. Pronounced aortic arteriosclerosis developed and was sharply localized to the aortic segment irradiated. Except in one dog, radiation-induced arteriosclerosis was more pronounced on the dorsal than on the ventral aortic wall. There was no evidence that severity of aortic arteriosclerosis was related to the dose of irradiation or was increased with time following irradiation. The development of arteriosclerotic lesions of the aorta induced by electron irradiation was similar to that observed after X-irradiation and to that occurring naturally in old dogs. It is suggested that electron irradiation may have caused selective injury of the internal elastic lamina, which was then followed by intimal fibrous proliferation and formation of intimal plaques. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- May 24, 1961
- Accession Number
- AD0259340
Entities
People
- C. Entenman
- S. Lindsay
Organizations
- Naval Radiological Defense Laboratory