ACCELERATION PROTECTION BY MEANS OF STIMULATION OF THE RETICULO-ENDOTHELIAL SYSTEM

Abstract

Stimulation of the rats' reticulo-endothelial system (RES) was effective in enhancing the tolerances to high G acceleration stress. Utilizing 10 daily consecutive intraperitoneal injections of endotoxin at increasing doses from 100 to 1200 micro grams, the median survival time of 122 rats undergoing 20 positive G acceleration was increased from a control level of 9.7 min to 14.2 min. One group of 48 rats has a median survival of 23.6 min compared to a control level of 11.3 min. The protective action of RES stimulation and the inhibitory action of RES blockade was effective in rats with normal or prolonged survival but not in rats with diminished tolerance before stimulatinn or blockade. An analysis of factors for optimal RES stimulation is presented as are possible mechanisms of action.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Jun 22, 1961
Accession Number
AD0260549

Entities

People

  • E. R. Stiehm

Organizations

  • Naval Air Warfare Center Warminster

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Animals
  • Blood
  • Body Weight
  • Bone Marrow
  • Cardiovascular Physiological Phenomena
  • Cells
  • Endothelial Cells
  • Endotoxins
  • Escherichia Coli
  • Government Procurement
  • Heart Rate
  • Hemorrhage
  • Hemorrhagic Shock
  • Infection
  • Lymphatic System
  • Macrophages
  • Particulate Matter

Fields of Study

  • Biology
  • Medicine
  • Psychology

Readers

  • Cardiovascular Physiology
  • Immunology