THE BIOCHEMICAL RELATIONSHIP BETWEEN NEUTRON AND ITS OLIGODENDROGLIA. MOLECULAR CHANGES IN THE RNA OF NERVE AND GLIA CELLS DURING LEARNING AND DURING EXPERIMENTALLY INCREASED RNA AND PROTEIN SYNTHESIS
Abstract
Fresh, isolated nerve cells or oligodendroglia have been analyzed with respect to RNA nucleotides, protein, respiratory enzyme activities, anaerobic glycolysis and ATP-ase activity. TheAMOUNT OF RNA nucleotides and protein has been expressed as micromicrograms per cell. Several new methods for the micromicrograms-range are described. The biochemical composition and enzyme activities were found to differ considerably in the nerve cell compared with its glia. Quantitative as well as qualitative differences could be produced by stimulation even down to the molecular level. They were found to be inversely related in the two types of cells of the neuron-glia complex. Evidence is presented that the nerve cell and the glia constitute a metabolic symbiosis. From an energetic point of view they form a coupled system. Based on these findings, the results are presented from a study of changes during learning experiments in rats. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 30, 1961
- Accession Number
- AD0262035
Entities
People
- Holger Hyden
Organizations
- University of Gothenburg