HAPTENIC PROPERTIES OF PARALYTIC SHELLFISH POISON

Abstract

In addition to completing orientation studies with non-toxic simulants for paralytic shellfish poison and a known haptenic system based on Hapamine, preliminary evidence was obtained which suggests the formation of a stabile diazo-derivative of the poison. This compound was given an opportunity to combine with ovalbumin, and the complex was used as the first experimental antigen. Failure of this preparation to elicit antibodies in rabbits was probably due to the fact that its toxicity prevented injection of sufficient antigen to develop a detectable titer. Plans are outlined for further chemical and immunological studies designed to overcome this difficulty.

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Document Details

Document Type
Technical Report
Publication Date
Oct 10, 1960
Accession Number
AD0263130

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Antibodies
  • Bioassay
  • Chemical Reactions
  • Chemical Synthesis
  • Chemistry
  • Couplings
  • Fish
  • Group 15 Elements
  • Health
  • Health Services
  • Histamine
  • Materials
  • Molecules
  • Proteins
  • Public Health
  • Sodium Hydroxide
  • Therapy

Readers

  • Oncology (Cancer Research).
  • Systems Analysis and Design
  • Virology (or Medical Virology).