RESEARCH ON THE EFFECTS OF DRUGS ON THE ACTIVITY OF SPINAL CORD INTERNEURONES, REGISTERED BY MEANS OF MICROELECTRODES

Abstract

A detailed analysis of the action of 1762 IS was made. The usual pharmacological procedures were used as well as a more specific technique which included a study of the modifications of the electrical activity at the various levels of the cerebro-spinal axis, the effects of the application to the cerebral and cerebellar cortex of the substance on the cortical electrical activity and its action on spinal integratory mechanisms. In preliminary toxicity studies, a synthetic compound, 4-formyl-4-phenylN-methyl-piperidine (1762 IS) showed convulsant properties very similar to those of strychnine. More detailed neuropharmacological investigations dealing with the action of 1762 IS on the cerebral electrical activity, on the mono-and polysnaptic reflexes and on the 'primary' spinal inhibition have confirmed the similarities between this compound and strychnine. Some relationships between structure and pharmacological properties are discussed. (Author)

Document Details

Document Type
Technical Report
Publication Date
Jul 01, 1961
Accession Number
AD0264820

Entities

People

  • Vincenzo G. Longo

Organizations

  • Istituto Superiore di Sanità

Tags

DTIC Thesaurus Topics

  • 1-Ring Heterocyclic Compounds
  • Anatomy
  • Biological Sciences
  • Brain
  • Central Nervous System
  • Central Nervous System Stimulants
  • Inhibition
  • Microelectrodes
  • Nervous System
  • Spinal Cord
  • Toxicity

Fields of Study

  • Psychology

Readers

  • Neuroscience
  • Theoretical Analysis.