RELATION OF HEPATIC INJURY TO HEPATIC FIBROSIS
Abstract
Various type of acute hepatic injury and of processes leading to and associated with hepatic fibrosis and cirrhosis were studied by fine structural and biochemical techniques. In subacute ethionine intoxication of the rat and in human viral hepatitis, the emphasis was laid on alterations of the endoplasmic reticulum. In cholestasis alterations of billary microvilli were followed by changes in other cytoplasmic organelles. In giant cell hepatitis of infancy, excess acid phosphatase distribution is conspicuous while in Wilson's disease a lysosomal alteration had been demonstrated. Hepatic steatosis in acute ethionine intoxication was associated with impairment of the catecholamine metabolism. The hepatic mesenchymal cells in part developing in response to liver injury were subdivided on a functional basis. Proliferation of bile ductules were found associated instead of with biliary obstruction with hydrocholeresis suggesting that these cells secrete an electrolyte rich fluid. Steroid therapy influences the florid but not the later stationary phase of subacute ethionine intoxication. A constant relation between hepatic hydroxyproline and DNA in various conditions with hepatic fibrosis suggests a role of cell proliferation in fiber formation. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 15, 1961
- Accession Number
- AD0264892
Entities
People
- Hans Popper
- Tibor Barka
Organizations
- Mount Sinai Hospital