THE LOCAL EFFECT OF GLYCERYL TRINITRATE, NITRITE, PAPAVERINE, AND ATROPINE UPON CORONARY VASCULAR RESISTANCE

Abstract

The effect of isotonic solutions of glyceryl trinitrate, sodium nitrite, papaverine hydrochloride, and atropine sulfate on coronary vascular resistance in the beating, non-working heart was studied in dogs during cardiopulmonary bypass. Evidence is presented which indicates that glyceryl trinitrate, nitrite, papaverine, and possibly atropine, produce active coronary vasodilation. A comparison of the active bases by weight allowed an estimation of their relative potencies. (Author)

Document Details

Document Type
Technical Report
Publication Date
Aug 28, 1961
Accession Number
AD0265050

Entities

People

  • E.d. Frohlich
  • J.b. Scott

Organizations

  • United States Army Medical Research Laboratory

Tags

DTIC Thesaurus Topics

  • Alkali Metals
  • Atropine
  • Chemical Compounds
  • Elements
  • Group 1 Elements
  • Metals
  • Nitroglycerin
  • Pharmaceutical Solutions
  • Resistance
  • Sodium
  • Sodium Compounds
  • Vasodilation

Fields of Study

  • Biology
  • Chemistry

Readers

  • Analytical Chemistry
  • Exercise and Sports Science.
  • Toxicology/Environmental Toxicology