PANCREATIC ISLET CELL TUMORS AND RENAL TUMORS IN THE MALE RAT FOLLOWING NEUTRON EXPOSURE
Abstract
NG TUDY OF THE LONG TERM AND LATE EFFECTS OF FAST NEUTRON EXPOSURE IN THE RAT A LAE NUMER OF PRIMARY PANCREATIC AND RENAL NEOPLASMS WAS OBSERVED AT AUTOPSY. The incidence of panceatic islet cell tumors among non-irradiated control animals was 17% whereas the same tumor was found in 56% of the animals exposed to 230 ads and 44% of those exposdto ads. Th fnctional significance, if any, of these tumors has not been established. Most of the animals with islet cell tu imary tumors in one or more of the other endocrine tissues although no specific pattrn of concomitant tumors was discernible. Renal neoplasms, in tao acinomas aional cell carcinomas, were found in 41% of the ni-mleose230ads and in 43%of tose exposed to 320 rads. No rna was observed in the non-irradiated controls derived from the same litters. This finding suggests that renal neoplasia in these rats is a response to radiation rather than an event in the normal aging process. On a rad dose basis neutrons are ore potent than x-rays for the induction of both islet cell and renal parenchmal tumors. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 27, 1961
- Accession Number
- AD0265226
Entities
People
- T.j. Castanera
- V.j. Rosen
Organizations
- Naval Radiological Defense Laboratory