A STUDY OF METHODS OF EQUILIBRATING TISSUE OXYGEN REQUIREMENTS AND TISSUE OXYGEN SUPPLY IN SHOCK AND SHOCK-LIKE STATES
Abstract
The secretion (microgram/min) and peripheral blood concentration of epinephrine (E), norepinephrine (N), 17-hydroxycorticosteroids (17-OHCS) and adrenal vein blood flow were measured in hemorrhagic shock: (1) bled to 60 mm Hg, maintained for 1 hr, then bled to 30 mm Hg and maintained for 1 hr; and (2) bled directly to 30 mm Hg, and maintained for 2 hr. In other experiments peripheral blood levels of E and N were followed during hypotension at 30, 45 and 60 mm Hg, maintained for 1.5, 2, 3, 4 and 6 hr. The adrenal response to shed blood replacement was also observed. With varying degrees and duration of hypotension a prompt increase in E, followed by a lesser and more variable increase in N, occurred in all groups. Blood reinfusion resulted in a sharp decrease to somewhat above control values of E and N when high secretion and blood levels were obtained at the time of transfusion. The adrenal vein blood 17-OHCS concentration usually increased at moderate levels of hypotension (60 mm Hg) although the microgram/min secretion may have decreased due to the reduction in blood flow. When the blood pressure was reduced to 30 mm Hg adrenal blood flow and corticoid secretion were markedly reduced to much lower levels. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 31, 1961
- Accession Number
- AD0265277
Entities
People
- Harry M. Vars
Organizations
- University of Pennsylvania