CUTANEOUS TOXICITY EVALUATION OF AIR FORCE DEVELOPMENT MATERIALS - IV

Abstract

Twelve Air Force development materials were studied via the prophetic patch test method on laboratory animals and volunteer human subjects to determine the primary irritant effect and the sensitization index of these materials. These materials were also studied by the Shelanski repeated insult patch test method on human volunteers to determine the primary irritation effect, fatiguing effect, and sensitization index. The patch test studies with rabbits indicated that only one material, Alkyldecalin, was too severe a primary irritant to test on humans. Upon testing the remaining materials on humans, Diethylcyclohexane was found to be a severe primary irritant. All other materials were found to be safe to use in contact with the human skin.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 1961
Accession Number
AD0265486

Entities

People

  • Karl L. Gabriel
  • Morris V. Shelanski

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Air Force
  • Air Force Facilities
  • Contracts
  • Government Procurement
  • Governments
  • Hydroxides
  • Irritants
  • Irritation
  • Laboratory Animals
  • Materials
  • Medical Laboratories
  • Medical Personnel
  • Public Health
  • Skin Diseases
  • Test Methods
  • Toxicity
  • United States

Readers

  • Aerospace logistics and air mobility.
  • Toxicology/Environmental Toxicology